RESUMO
A new isopimarane-type diterpenoid, crolaevinoid A, along with four known analogues was isolated from the twigs and leaves of Croton laevigatus. The structures of the isolated compounds were established on the basis of NMR and MS spectroscopic analyses. The isolated compounds were examined the antibacterial activities. Unfortunately, the compounds showed no antibacterial activity against Micrococcus luteus, Methicillin-resistant Staphylococcus aureus, Aeromonas hydrophila, Klebsiella pneumoniae ssp pneumoniae, Acinetobacter Baumanii, and Escherichia coli.
Assuntos
Abietanos/química , Antibacterianos/farmacologia , Croton/química , Diterpenos/química , Diterpenos/farmacologia , Antibacterianos/química , Diterpenos/isolamento & purificação , Avaliação Pré-Clínica de Medicamentos , Espectroscopia de Ressonância Magnética , Staphylococcus aureus Resistente à Meticilina , Testes de Sensibilidade Microbiana , Estrutura Molecular , Folhas de Planta/química , Espectrometria de Massas por Ionização por ElectrosprayRESUMO
Euphorpekone A (1) and euphorpekone B (2), two new diterpenoids, 3ß-hydroxy-25-methyloxylanosta-8,23-diene, a new triterpenoid (3), together with a known triterpenoid, 3ß,25-dihydroxylanosta-8,23-diene (4), were isolated from Euphorbia pekinensis Rupr. Their structures were elucidated on the basis of UV, IR, 1D ((1)H, (13)C, NOE) and 2D ((1)H-(1)H COSY, HSQC, HMBC) NMR, HR-ESI-MS, X-ray diffraction analysis, and CD method.
